If you have an internal Design Table:
-New configurations: should be auto created with their settings when you exit Design Table editing.
-Existing configurations: You could set up the configurations to auto rebuild/update upon save (Open model, click on Configurations tab like normal to see configurations, select all configurations, right click, choose 'Add Rebuild/Save Mark'). This means each time you save it rebuilds all configurations with this option turned on (can turn off later if needed or apply to only certain configurations. I've heard of people running macro's to auto update as well but I'm not familiar with those.
-Have not tried this with externally saved/linked Design Tables.