Are there any CAD softwares that use hand gestures?
There are several "3D mice" that aim to solve this "problem".
I've tried them, but never found them to be useful.
Keyboard and mouse are the primary tools to use the computer, if a new tool (i.e. 3D mouse, glove, vr headset) is added, then the user spends much of their time changing between the different tools.
Siemens NX implemented some of this in NX10, though I don't know how I'd feel after holding my arms up all day to touch screens and make gestures. Might make CAD work feasible with a touchscreen interface though.
I'm set in my ways at this point with a keyboard, mouse and spacecontroller.